Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
نویسندگان
چکیده
منابع مشابه
Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
TRPM2 is a Ca(2+)-permeable nonselective cation channel that plays important roles in oxidative stress-mediated cell death and inflammation processes. However, how TRPM2 is regulated under physiological and pathological conditions is not fully understood. Here, we report that both intracellular and extracellular protons block TRPM2 by inhibiting channel gating. We demonstrate that external prot...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2009
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200910254